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OpenTG-GATEs
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About this database

TGP(The Toxicogenomics Project)is a joint government-private sector project organized by the National Institute of Biomedical Innovation, National Institute of Health Sciences and 15 pharmaceutical companies. Between 2002 and 2006, the TGP gathered data on gene expression and toxicity in rats and the primary cultured hepatocytes of rats and humans following exposure to 150 compounds (pharmaceutical products, etc.), and used this data to build a large-scale, high-quality toxicogenomics database.(Toxicogenomics Project-Genomics Assisted Toxicity Evaluation system)was then developed by adding analysis and toxicity prediction capabilities to the database systems.

TGP2(The Toxicogenomics Informatics Project) is a follow-on project from TGP, organized by the National Institute of Biomedical Innovation, National Institute of Health Sciences and 13 companies. Between 2007 and 2011, this project discovered over 30 different safety biomarkers using TG-GATEs. The additional data obtained by TGP2 for verifying the biomarkers and analyzing their mechanisms has been incorporated into TG-GATEs.

Open TG-GATEs is a public toxicogenomics database developed so that a wider community of researchers could utilize the fruits of TGP and TGP2 research. This database provides public access to data on 170 of the compounds catalogued in TG-GATEs. Data searching can be refined using either the name of a compound or the pathological findings by organ as the starting point. Gene expression data linked to phenotype data in pathology findings can also be downloaded as a CEL(*)file.

Open TG-GATEs has led to the publication of the following research, supported in part by a Health and Labour Sciences Research Grant and by the collaborating companies.
  1. Research project: Construction of Drug Safety Prediction System by Toxicogenomics Technology and Related Basic Research
    (Project No. (ID):H14-Toxico-001)
  2. Research project: Drug Safety Assessment Based on Toxicity Mechanisms using Toxicogenomics Database
    (Project No.(ID):H19-Toxico-001)
We are grateful to the many researchers, technicians and IT staff who took part in these projects and made it possible to open this database to the public.
National Institutes of Biomedical Innovation, Health and Nutrition
Toxicogenomics Informatics Project


(*)CEL is one of the file formats that expresses gene expression data (raw data) obtained using the Affymetrix GeneChip®.