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公開データ一覧

公開対象 in vivoデータ
   化合物名(英) 溶媒 投与経路 臓器 単回試験投与量
(mg/kg)
反復試験投与量
(mg/kg)
備考
Low Middle High Low Middle High
1 acetaminophen 0.5% MC Gavage Liver /
Kidney
300 600 1000 300 600 1000  
2 isoniazid 0.5% MC Gavage Liver 200 600 2000 50 100 200  
3 carbon tetrachloride corn oil Gavage Liver 30 100 300 30 100 300  
4 phenobarbital 0.5% MC Gavage Liver 100 150 300 10 30 100  
5 valproic acid 0.5% MC Gavage Liver /
Kidney
45 150 450 45 150 450  
6 clofibrate corn oil Gavage Liver /
Kidney
30 100 300 30 100 300  
7 rifampicin 0.5% MC Gavage Liver /
Kidney
20 60 200 20 60 200  
8 naphthyl isothiocyanate corn oil Gavage Liver 15 50 150 1.5 5 15  
9 allyl alcohol corn oil Gavage Liver /
Kidney
3 10 30 3 10 30  
10 phenylbutazone 0.5% MC Gavage Liver /
Kidney
20 60 200 20 60 200  
11 omeprazole 0.5% MC Gavage Liver /
Kidney
100 300 1000 100 300 1000  
12 ethionine 0.5% MC Gavage Liver /
Kidney
25 80 250 25 80 250  
13 aspirin 0.5% MC Gavage Liver 450 1000 2000 45 150 450  
14 indomethacin 0.5% MC Gavage Liver 5 15 50 0.5 1.6 5  
Kidney 0.5 1.6 5 0.5 1.6 5  
15 chlorpromazine 0.5% MC Gavage Liver 45 150 NoData 4.5 15 45  
16 thioacetamide 0.5% MC Gavage Liver /
Kidney
4.5 15 45 4.5 15 45  
17 carbamazepine 0.5% MC Gavage Liver 30 100 300 30 100 300  
18 diclofenac 0.5% MC Gavage Liver 10 30 100 1 3 10  
19 nitrofurantoin 0.5% MC Gavage Liver 100 300 600 10 30 100  
Kidney 10 30 100 10 30 100  
20 benzbromarone 0.5% MC Gavage Liver 20 60 200 20 60 200  
21 hexachlorobenzene corn oil Gavage Liver /
Kidney
300 1000 2000 30 100 300  
22 diazepam 0.5% MC Gavage Liver 25 75 250 25 75 250  
23 cyclophosphamide 0.5% MC Gavage Liver 15 50 150 1.5 5 15  
Kidney 1.5 5 15 1.5 5 15  
24 methapyrilene 0.5% MC Gavage Liver 10 30 100 10 30 100  
25 phenytoin 0.5% MC Gavage Liver 600 1200 2000 60 200 600  
26 coumarin corn oil Gavage Liver 15 50 150 15 50 150  
27 allopurinol 0.5% MC Gavage Liver /
Kidney
15 50 150 15 50 150  
28 propylthiouracil 0.5% MC Gavage Liver 10 30 100 10 30 100  
29 WY-14643 corn oil Gavage Liver 10 30 100 10 30 100  
30 gemfibrozil corn oil Gavage Liver 30 100 300 30 100 300  
31 bromobenzene corn oil Gavage Liver /
Kidney
30 100 300 30 100 300  
32 amiodarone 0.5% MC Gavage Liver 200 600 2000 20 60 200  
33 sulfasalazine 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
34 cimetidine 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
35 haloperidol 0.5% MC Gavage Liver 3 10 30 3 10 30  
36 fluphenazine 0.5% MC Gavage Liver 2 6 20 2 6 20  
37 thioridazine 0.5% MC Gavage Liver 10 30 100 10 30 100  
38 adapin 0.5% MC Gavage Liver 100 300 NoData 10 30 100  
39 labetalol 0.5% MC Gavage Liver 45 150 450 45 150 450  
40 methyltestosterone 0.5% MC Gavage Liver /
Kidney
30 100 300 30 100 300  
41 glibenclamide corn oil Gavage Liver 100 300 1000 100 300 1000  
42 griseofulvin corn oil Gavage Liver 100 300 1000 100 300 1000  
43 flutamide corn oil Gavage Liver 15 50 150 15 50 150  
44 perhexiline 0.5% MC Gavage Liver 15 50 150 15 50 150  
45 azathioprine 0.5% MC Gavage Liver 3 10 30 3 10 30  
46 ketoconazole 0.5% MC Gavage Liver /
Kidney
10 30 100 10 30 100  
47 tetracycline 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
48 lomustine 0.5% MC Gavage Liver /
Kidney
0.6 2 6 0.6 2 6  
49 ciprofloxacin 0.5% MC Gavage Liver /
Kidney
100 300 1000 100 300 1000  
50 pemoline 0.5% MC Gavage Liver 7.5 25 75 7.5 25 75  
51 chlormezanone corn oil Gavage Liver 50 150 500 50 150 500  
52 metformin 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
53 tamoxifen corn oil Gavage Liver 6 20 60 6 20 60  
54 ethinylestradiol corn oil Gavage Liver /
Kidney
1 3 10 1 3 10  
55 methyldopa corn oil Gavage Liver 60 200 600 60 200 600  
56 methimazole 0.5% MC Gavage Liver 10 30 100 10 30 100  
57 monocrotaline 0.5% MC Gavage Liver /
Kidney
3 10 30 3 10 30  
58 vitamin A corn oil Gavage Liver 10 30 100 10 30 100  
59 tacrine 0.5% MC Gavage Liver 3 10 30 3 10 30  
60 moxisylyte 0.5% MC Gavage Liver 50 150 500 50 150 500  
61 iproniazid 0.5% MC Gavage Liver 6 20 60 6 20 60  
62 chloramphenicol 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
63 nitrofurazone 0.5% MC Gavage Liver 30 100 300 10 30 100  
64 imipramine 0.5% MC Gavage Liver /
Kidney
10 30 100 10 30 100  
65 amitriptyline 0.5% MC Gavage Liver 15 50 150 15 50 150  
66 hydroxyzine 0.5% MC Gavage Liver 10 30 100 10 30 100  
67 ibuprofen 0.5% MC Gavage Liver 60 200 400 20 60 200  
68 naproxen 0.5% MC Gavage Liver 20 60 200 6 20 60  
69 quinidine 0.5% MC Gavage Liver 20 60 200 20 60 200  
70 furosemide 0.5% MC Gavage Liver 30 100 300 30 100 300  
71 fenofibrate 0.5% MC Gavage Liver 10 100 1000 10 100 1000  
72 chlorpropamide 0.5% MC Gavage Liver 30 100 300 30 100 300  
73 nicotinic acid 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
74 erythromycin ethylsuccinate 0.5% MC Gavage Liver /
Kidney
100 300 1000 100 300 1000  
75 ethambutol 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
76 mefenamic acid 0.5% MC Gavage Liver 30 100 300 30 100 300  
77 famotidine 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
78 ranitidine 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
79 chlorpheniramine 0.5% MC Gavage Liver 3 10 30 3 10 30  
80 nifedipine 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
81 diltiazem 0.5% MC Gavage Liver 80 240 800 80 240 800  
82 tannic acid 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
83 captopril 0.5% MC Gavage Liver /
Kidney
100 300 1000 100 300 1000  
84 enalapril 0.5% MC Gavage Liver /
Kidney
60 200 600 60 200 600  
85 theophylline 0.5% MC Gavage Liver 20 60 200 20 60 200  
86 caffeine 0.5% MC Gavage Liver /
Kidney
10 30 100 10 30 100  
87 papaverine 0.5% MC Gavage Liver 40 120 400 40 120 400  
88 penicillamine 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
89 sulindac 0.5% MC Gavage Liver 15 50 150 5 15 50  
90 triamterene 0.5% MC Gavage Liver /
Kidney
15 50 150 15 50 150  
91 disopyramide 0.5% MC Gavage Liver 40 120 400 40 120 400  
92 mexiletine 0.5% MC Gavage Liver 40 120 400 40 120 400  
93 tiopronin 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
94 acetazolamide 0.5% MC Gavage Liver /
Kidney
60 200 600 60 200 600  
95 disulfiram 0.5% MC Gavage Liver 60 200 600 60 200 600  
96 promethazine 0.5% MC Gavage Liver 20 60 200 20 60 200  
97 colchicine 0.5% MC Gavage Liver 1.5 5 15 0.5 1.5 5  
98 tolbutamide 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
99 sulpiride 0.5% MC Gavage Liver 300 1000 2000 100 300 1000  
100 acarbose 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
101 simvastatin 0.5% MC Gavage Liver 40 120 400 40 120 400  
102 ajmaline 0.5% MC Gavage Liver 30 100 300 30 100 300  
103 dantrolene 0.5% MC Gavage Liver 25 75 250 25 75 250  
104 triazolam 0.5% MC Gavage Liver 100 300 1000 100 300 1000  
105 clomipramine 0.5% MC Gavage Liver 10 30 100 10 30 100  
106 trimethadione 0.5% MC Gavage Liver 50 150 500 50 150 500  
107 terbinafine 0.5% MC Gavage Liver 75 250 750 75 250 750  
108 meloxicam 0.5% MC Gavage Liver 10 30 100 3 10 30  
109 lornoxicam 0.5% MC Gavage Liver 1 3 10 0.3 1 3  
110 chlormadinone 0.5% MC Gavage Liver 300 1000 2000 100 300 1000  
111 danazol 0.5% MC Gavage Liver 300 1000 2000 100 300 1000  
112 bendazac 0.5% MC Gavage Liver 100 300 1000 30 100 300  
113 benziodarone 0.5% MC Gavage Liver 30 100 300 30 100 300  
114 etoposide 0.5% MC Gavage Liver 10 100 1000 3 10 30  
115 cisplatin saline intravenous injection Liver /
Kidney
0.3 1 3 0.1 0.3 1  
116 carboplatin saline intravenous injection Liver /
Kidney
10 30 100 1 3 10  
117 bromoethylamine saline intravenous injection Liver /
Kidney
6 20 60 2 6 20  
118 ethionamide 0.5% MC Gavage Liver 100 300 1000 30 100 300  
119 nimesulide 0.5% MC Gavage Liver 30 100 300 10 30 100  
120 ethanol distilled water Gavage Liver 400 1200 4000 400 1200 4000  
121 phenacetin 0.5% MC Gavage Liver /
Kidney
300 1000 2000 100 300 1000  
122 bucetin 0.5% MC Gavage Liver /
Kidney
300 1000 2000 100 300 1000  
123 phenylanthranilic acid 0.5% MC Gavage Liver /
Kidney
300 1000 2000 100 300 1000  
124 cephalothin saline intravenous injection Liver /
Kidney
300 1000 2000 300 1000 2000  
125 cyclosporine A corn oil Gavage Liver /
Kidney
30 100 300 10 30 100  
126 puromycin aminonucleoside saline intravenous injection Liver /
Kidney
12 40 120 4 12 40  
127 acetamidofluorene 0.5% MC Gavage Liver 100 300 1000 30 100 300  
128 nitrosodiethylamine 0.5% MC Gavage Liver 10 30 100 3 10 30  
129 ticlopidine 0.5% MC Gavage Liver 100 300 1000 30 100 300  
130 gentamicin saline intravenous injection Liver /
Kidney
10 30 100 10 30 100  
131 doxorubicin saline intravenous injection Liver /
Kidney
1 3 10 0.1 0.3 1  
132 rosiglitazone maleate 0.5% MC Gavage Liver 20 100 500 2 20 100  
133 rotenone 0.5% MC Gavage Liver 5 15 50 5 15 50  
134 dexamethasone 0.5% MC Gavage Liver 0.5 5 50 NoData NoData NoData  
135 2,4-dinitrophenol 0.5% MC Gavage Liver 6 20 60 6 20 60  
136 methylene dianiline corn oil Gavage Liver 30 100 300 10 30 100  
137 butylated hydroxyanisole corn oil Gavage Liver 300 1000 2000 300 1000 2000  
138 amphotericin B 5% glucose sol., 1% DMSO, 0.001N HCl intravenous injection Liver /
Kidney
0.6 2 4 0.1 0.3 1  
139 fluoxetine hydrochloride 0.5% MC Gavage Liver 3 10 30 3 10 30  
140 desmopressin acetate saline subcutaneous injection Liver /
Kidney
20 200 2000 2 20 200  
141 2-nitrofluorene corn oil Gavage Liver 100 300 1000 NoData NoData NoData  
142 1% cholesterol + 0.25% sodium cholate none Diet Liver NoData NoData NoData NoData NoData 9999  
143 N-nitrosomorpholine 0.5% MC Gavage Liver 100 300 600 NoData NoData NoData  
144 N-methyl-N-nitrosourea saline intraperitoneal injection Liver 10 30 100 NoData NoData NoData  
145 aflatoxin B1 0.5% MC Gavage Liver 1 3 10 NoData NoData NoData  
146 3-methylcholanthrene corn oil Gavage Liver 10 30 100 NoData NoData NoData  
147 acetamide 0.5% MC Gavage Liver NoData NoData NoData 300 1000 2000  
148 propranolol 0.5% MC Gavage Liver 15 50 150 15 50 150  
149 alpidem NoData NoData NoData NoData NoData NoData NoData NoData NoData  
150 venlafaxine NoData NoData NoData NoData NoData NoData NoData NoData NoData  
151 buspirone NoData NoData NoData NoData NoData NoData NoData NoData NoData  
152 clozapine NoData NoData NoData NoData NoData NoData NoData NoData NoData  
153 nefazodone NoData NoData NoData NoData NoData NoData NoData NoData NoData  
154 interferon alpha, human NoData NoData NoData NoData NoData NoData NoData NoData NoData  
155 interleukin 1 beta, human NoData NoData NoData NoData NoData NoData NoData NoData NoData  
156 interleukin 6, human NoData NoData NoData NoData NoData NoData NoData NoData NoData  
157 transforming growth factor beta 1 NoData NoData NoData NoData NoData NoData NoData NoData NoData  
158 hepatocyte growth factor, human NoData NoData NoData NoData NoData NoData NoData NoData NoData  
159 bortezomib saline intravenous injection Liver 0.1 0.3 0.6 NoData NoData NoData  
160 gefitinib 0.5% MC Gavage Liver 200 600 2000 NoData NoData NoData  
161 imatinib, methanesulfonate salt 0.5% MC Gavage Liver 60 200 600 NoData NoData NoData  
162 cycloheximide saline intravenous injection Liver 1 3 10 NoData NoData NoData  
163 tunicamycin saline intraperitoneal injection Liver 30 100 300 NoData NoData NoData  
164 phorone corn oil intraperitoneal injection Liver 40 120 400 NoData NoData NoData  
165 buthionine sulfoximine saline intraperitoneal injection Liver 150 450 1500 NoData NoData NoData  
166 diethyl maleate corn oil intraperitoneal injection Liver 80 240 800 NoData NoData NoData  
167 galactosamine saline intraperitoneal injection Liver 100 300 1000 NoData NoData NoData  
168 LPS saline intraperitoneal injection Liver 10 300 3000 NoData NoData NoData  
169 TNFα 0.5% BSA saline intraperitoneal injection Liver 1 3 10 NoData NoData NoData  
170 phalloidin saline intraperitoneal injection Liver NoData NoData 0.5 NoData NoData 0.5  
公開対象 in vitroデータ
   化合物名(英) 溶媒 Cell Rat試験投与量
(μM)
Human試験投与量
(μM)
備考
Low Middle High Low Middle High
1 acetaminophen medium Hepatocyte 1000 3000 10000 200 1000 5000  
2 isoniazid medium Hepatocyte 400 2000 10000 400 2000 10000  
3 carbon tetrachloride DMSO Hepatocyte 1000 3000 10000 300 1500 7500  
4 phenobarbital medium Hepatocyte 1000 3000 10000 400 2000 10000  
5 valproic acid medium Hepatocyte 400 2000 10000 200 1000 5000  
6 clofibrate DMSO Hepatocyte 12 60 300 12 60 300  
7 rifampicin DMSO Hepatocyte 2.8 14 70 2.8 14 70  
8 naphthyl isothiocyanate DMSO Hepatocyte 8 40 200 8 40 200  
9 allyl alcohol medium Hepatocyte 0.8 4 20 2.8 14 70  
10 phenylbutazone DMSO Hepatocyte 16 80 400 16 80 400  
11 omeprazole DMSO Hepatocyte 4.8 24 120 24 120 600  
12 ethionine medium Hepatocyte 400 2000 10000 400 2000 10000  
13 aspirin DMSO Hepatocyte 120 600 3000 120 600 3000  
14 indomethacin DMSO Hepatocyte 12 60 300 8 40 200  
15 chlorpromazine DMSO Hepatocyte 0.8 4 20 0.8 4 20  
16 thioacetamide medium Hepatocyte 400 2000 10000 400 2000 10000  
17 carbamazepine DMSO Hepatocyte 12 60 300 12 60 300  
18 diclofenac DMSO Hepatocyte 16 80 400 16 80 400  
19 nitrofurantoin DMSO Hepatocyte 5 25 125 5 25 125  
20 benzbromarone DMSO Hepatocyte 0.6 3 15 4 20 100  
21 hexachlorobenzene DMSO Hepatocyte 0.6 3 15 1.2 6 30  
22 diazepam DMSO Hepatocyte 5 25 125 10 50 250  
23 cyclophosphamide medium Hepatocyte 8 40 200 80 400 2000  
24 methapyrilene medium Hepatocyte 0.6 3 15 24 120 600  
25 phenytoin DMSO Hepatocyte 2.4 12 60 2.4 12 60  
26 coumarin DMSO Hepatocyte 12 60 300 12 60 300  
27 allopurinol DMSO Hepatocyte 5.6 28 140 5.6 28 140  
28 propylthiouracil medium Hepatocyte 160 800 4000 160 800 4000  
29 WY-14643 DMSO Hepatocyte 8 40 200 6 30 150  
30 gemfibrozil DMSO Hepatocyte 4 20 100 4 20 100  
31 bromobenzene DMSO Hepatocyte 8 40 200 8 40 200  
32 amiodarone DMSO Hepatocyte 0.28 1.4 7 0.28 1.4 7  
33 sulfasalazine DMSO Hepatocyte 4 20 100 6 30 150  
34 cimetidine DMSO Hepatocyte 12 60 300 12 60 300  
35 haloperidol DMSO Hepatocyte 2 10 50 0.8 4 20  
36 fluphenazine medium Hepatocyte 1.2 6 30 0.8 4 20  
37 thioridazine DMSO Hepatocyte 0.4 2 10 0.6 3 15  
38 adapin DMSO Hepatocyte 3 15 75 3 15 75  
39 labetalol medium Hepatocyte 5.6 28 140 5.6 28 140  
40 methyltestosterone DMSO Hepatocyte 1.6 8 40 0.8 4 20  
41 glibenclamide DMSO Hepatocyte 2.4 12 60 0.8 4 20  
42 griseofulvin DMSO Hepatocyte 1.2 6 30 0.8 4 20  
43 flutamide DMSO Hepatocyte 3 15 75 2 10 50  
44 perhexiline DMSO Hepatocyte 0.4 2 10 0.6 3 15  
45 azathioprine DMSO Hepatocyte 0.14 0.72 3.6 2.9 14.6 72.8  
46 ketoconazole DMSO Hepatocyte 0.6 3 15 0.6 3 15  
47 tetracycline DMSO Hepatocyte 1 5 25 1 5 25  
48 lomustine DMSO Hepatocyte 4.8 24 120 4.8 24 120  
49 ciprofloxacin DMSO Hepatocyte 1 5 25 NoData 5 25  
50 pemoline DMSO Hepatocyte 3 15 75 NoData 15 75  
51 chlormezanone DMSO Hepatocyte 10 50 250 NoData 50 250  
52 metformin medium Hepatocyte 40 200 1000 NoData 200 1000  
53 tamoxifen DMSO Hepatocyte 0.12 0.6 3 NoData 5 25  
54 ethinylestradiol DMSO Hepatocyte 0.6 3 15 NoData 3 15  
55 methyldopa medium Hepatocyte 2 10 50 NoData 10 50  
56 methimazole medium Hepatocyte 400 2000 10000 NoData 2000 10000  
57 monocrotaline DMSO Hepatocyte 3.6 18 90 NoData 18 90  
58 vitamin A DMSO Hepatocyte 0.3 1.5 7.5 NoData 1.5 7.5  
59 tacrine medium Hepatocyte 8 40 200 NoData 16 80  
60 moxisylyte medium Hepatocyte 24 120 600 NoData 80 400  
61 iproniazid medium Hepatocyte 80 400 2000 NoData 240 1200  
62 chloramphenicol DMSO Hepatocyte 18 90 450 NoData 90 450  
63 nitrofurazone DMSO Hepatocyte 12 60 300 NoData 10 50  
64 imipramine DMSO Hepatocyte 4 20 100 NoData 3 15  
65 amitriptyline DMSO Hepatocyte 2.4 12 60 NoData 3 15  
66 hydroxyzine medium Hepatocyte 6 30 150 NoData 8 40  
67 ibuprofen medium Hepatocyte 40 200 1000 NoData 30 150  
68 naproxen medium Hepatocyte 80 400 2000 NoData 120 600  
69 quinidine medium Hepatocyte 8 40 200 NoData 10 50  
70 furosemide medium Hepatocyte 100 500 2500 NoData 500 2500  
71 fenofibrate DMSO Hepatocyte 1.2 6 30 NoData 6 30  
72 chlorpropamide DMSO Hepatocyte 30 150 750 NoData 150 750  
73 nicotinic acid medium Hepatocyte 400 2000 10000 NoData 2000 10000  
74 erythromycin ethylsuccinate DMSO Hepatocyte 3 15 75 NoData 1 5  
75 ethambutol medium Hepatocyte 160 800 4000 NoData 800 4000  
76 mefenamic acid DMSO Hepatocyte 6 30 150 NoData 30 150  
77 famotidine DMSO Hepatocyte 28 140 700 NoData 140 700  
78 ranitidine medium Hepatocyte 160 800 4000 NoData 800 4000  
79 chlorpheniramine medium Hepatocyte 8 40 200 NoData 18 90  
80 nifedipine DMSO Hepatocyte 10 50 250 NoData 30 150  
81 diltiazem DMSO Hepatocyte 10 50 250 NoData 30 150  
82 tannic acid DMSO Hepatocyte 0.4 2 10 NoData 1 5  
83 captopril medium Hepatocyte 400 2000 10000 NoData 1600 8000  
84 enalapril medium Hepatocyte 80 400 2000 NoData 400 2000  
85 theophylline medium Hepatocyte 400 2000 10000 NoData 2000 10000  
86 caffeine medium Hepatocyte 400 2000 10000 NoData 1500 7500  
87 papaverine medium Hepatocyte 4 20 100 NoData 12 60  
88 penicillamine medium Hepatocyte 400 2000 10000 NoData 2000 10000  
89 sulindac medium Hepatocyte 80 400 2000 NoData 600 3000  
90 triamterene DMSO Hepatocyte 1.2 6 30 NoData NoData NoData  
91 disopyramide medium Hepatocyte 100 500 2500 NoData 700 3500  
92 mexiletine medium Hepatocyte 0.6 3 15 NoData 60 300  
93 tiopronin medium Hepatocyte 1 5 25 NoData 400 2000  
94 acetazolamide DMSO Hepatocyte 24 120 600 NoData 120 600  
95 disulfiram DMSO Hepatocyte 2.4 12 60 NoData 12 60  
96 promethazine DMSO Hepatocyte 3.2 16 80 NoData 7 35  
97 colchicine medium Hepatocyte 200 1000 5000 NoData 800 4000  
98 tolbutamide medium Hepatocyte 80 400 2000 NoData 400 2000  
99 sulpiride medium Hepatocyte 200 1000 5000 NoData 1000 5000  
100 acarbose medium Hepatocyte 400 2000 10000 NoData 2000 10000  
101 simvastatin DMSO Hepatocyte 2.4 12 60 NoData 6 30  
102 ajmaline DMSO Hepatocyte 12 60 300 NoData 60 300  
103 dantrolene DMSO Hepatocyte 0.4 2 10 NoData 2 10  
104 triazolam DMSO, 0.5% DMSO Hepatocyte 0.4 2 10 0.4 2 10  
105 clomipramine DMSO Hepatocyte 1.6 8 40 NoData 2 10  
106 trimethadione medium Hepatocyte 400 2000 10000 400 2000 10000  
107 terbinafine DMSO Hepatocyte 0.6 3 15 NoData 3 15  
108 meloxicam DMSO Hepatocyte 2 10 50 NoData 10 50  
109 lornoxicam DMSO Hepatocyte 0.6 3 15 NoData 3 15  
110 chlormadinone DMSO Hepatocyte 1.6 8 40 NoData 8 40  
111 danazol DMSO Hepatocyte 1.4 7 35 NoData 7 35  
112 bendazac medium Hepatocyte 8 40 200 8 40 200  
113 benziodarone DMSO Hepatocyte 1 5 25 NoData 8 40  
114 etoposide DMSO Hepatocyte 14 70 350 NoData 66 330  
115 cisplatin DMSO Hepatocyte 8 40 200 NoData NoData NoData  
116 carboplatin medium Hepatocyte 120 600 3000 NoData NoData NoData  
117 bromoethylamine medium Hepatocyte 20 100 500 20 100 500  
118 ethionamide DMSO Hepatocyte 24 120 600 NoData 120 600  
119 nimesulide DMSO Hepatocyte 3 15 75 NoData 66 330  
120 ethanol medium Hepatocyte 400 2000 10000 NoData 2000 10000  
121 phenacetin DMSO Hepatocyte 24 120 600 NoData 120 600  
122 bucetin DMSO Hepatocyte 12 60 300 NoData 60 300  
123 phenylanthranilic acid DMSO Hepatocyte 8 40 200 NoData 40 200  
124 cephalothin medium Hepatocyte 120 600 3000 NoData NoData NoData  
125 cyclosporine A DMSO, 0.5% DMSO Hepatocyte 0.24 1.2 6 0.24 1.2 6  
126 puromycin aminonucleoside medium Hepatocyte 100 500 2500 NoData NoData NoData  
127 acetamidofluorene DMSO Hepatocyte 2 10 50 NoData 10 50  
128 nitrosodiethylamine medium Hepatocyte 400 2000 10000 NoData 2000 10000  
129 ticlopidine DMSO Hepatocyte 2.4 12 60 NoData 4 20  
130 gentamicin medium Hepatocyte 1.2 6 30 NoData NoData NoData 投与量単位はmg/mL
131 doxorubicin DMSO, 0.5% DMSO Hepatocyte 0.08 0.4 2 0.4 2 10  
132 rosiglitazone maleate 0.5% DMSO Hepatocyte NoData NoData NoData 12 60 300  
133 rotenone medium Hepatocyte NoData NoData NoData 0.08 0.4 2  
134 dexamethasone 0.5% DMSO Hepatocyte NoData NoData NoData 12 60 300  
135 2,4-dinitrophenol medium Hepatocyte NoData NoData NoData 4 20 100  
136 methylene dianiline medium Hepatocyte NoData NoData NoData 24 120 600  
137 butylated hydroxyanisole medium Hepatocyte NoData NoData NoData 8 40 200  
138 amphotericin B DMSO Hepatocyte NoData NoData NoData 0.08 0.4 2  
139 fluoxetine hydrochloride DMSO Hepatocyte NoData NoData NoData 4 8 20  
140 desmopressin acetate NoData NoData NoData NoData NoData NoData NoData NoData  
141 2-nitrofluorene 0.5% DMSO Hepatocyte NoData NoData NoData 4 20 100  
142 1% cholesterol + 0.25% sodium cholate NoData NoData NoData NoData NoData NoData NoData NoData  
143 N-nitrosomorpholine medium Hepatocyte NoData NoData NoData 400 2000 10000  
144 N-methyl-N-nitrosourea medium Hepatocyte NoData NoData NoData 1200 6000 10000  
145 aflatoxin B1 DMSO Hepatocyte NoData NoData NoData 0.24 1.2 6  
146 3-methylcholanthrene NoData NoData NoData NoData NoData NoData NoData NoData  
147 acetamide medium Hepatocyte NoData NoData NoData 400 2000 10000  
148 propranolol medium Hepatocyte NoData NoData NoData 6 30 100  
149 alpidem DMSO Hepatocyte 10 NoData NoData NoData 3 10  
150 venlafaxine medium Hepatocyte 1200 NoData NoData NoData 240 1200  
151 buspirone medium Hepatocyte 70 NoData NoData NoData 6 30  
152 clozapine DMSO Hepatocyte 120 NoData NoData NoData 10 50  
153 nefazodone DMSO Hepatocyte 70 NoData NoData NoData 6 30  
154 interferon alpha, human medium Hepatocyte NoData NoData NoData 2 10 50  
155 interleukin 1 beta, human medium Hepatocyte NoData NoData NoData 2 10 50  
156 interleukin 6, human medium Hepatocyte NoData NoData NoData 2 10 50  
157 transforming growth factor beta 1 medium Hepatocyte NoData NoData NoData 2 10 50  
158 hepatocyte growth factor, human medium Hepatocyte NoData NoData NoData 2 10 50  
159 bortezomib NoData NoData NoData NoData NoData NoData NoData NoData  
160 gefitinib NoData NoData NoData NoData NoData NoData NoData NoData  
161 imatinib, methanesulfonate salt NoData NoData NoData NoData NoData NoData NoData NoData  
162 cycloheximide medium Hepatocyte 4 20 100 4 20 100  
163 tunicamycin medium Hepatocyte 2 10 50 0.4 2 10  
164 phorone medium Hepatocyte 20 100 500 200 1000 5000  
165 buthionine sulfoximine medium Hepatocyte 400 2000 10000 400 2000 10000  
166 diethyl maleate medium Hepatocyte 60 300 1500 60 300 1500  
167 galactosamine medium Hepatocyte 400 2000 10000 400 2000 10000  
168 LPS medium Hepatocyte 0.16 0.8 4 12 60 300  
169 TNFα medium Hepatocyte 2 10 50 2 10 50  
170 phalloidin medium, 0.5% DMSO Hepatocyte 4 20 100 16 80 400